PT  - JOURNAL ARTICLE
AU  - Shlomovitz, Eran
AU  - Davies, Ward
AU  - Cairns, Ewa
AU  - Brintnell, William C.
AU  - Goldszmidt, Mark
AU  - Dresser, George K.
TI  - Severe necrotizing pancreatitis following combined hepatitis A and B vaccination
AID  - 10.1503/cmaj.060360
DP  - 2007 Jan 30
TA  - Canadian Medical Association Journal
PG  - 339--342
VI  - 176
IP  - 3
4099  - http://www.cmaj.ca/content/176/3/339.short
4100  - http://www.cmaj.ca/content/176/3/339.full
SO  - CMAJ2007 Jan 30; 176
AB  - Necrotizing pancreatitis is a severe form of pancreatitis and is associated with substantial morbidity and mortality. We report a case of necrotizing pancreatitis that developed following combined hepatitis A and B vaccination. No other causes of pancreatitis could be determined. Although confirming the diagnosis is challenging, 3 main factors suggest a possible link to the vaccine: the chronology of the events, the patient's human leukocyte antigen genotype and the incongruent immune response to the vaccine components. This report serves to alert physicians to the possible development of necrotizing pancreatitis after vaccination.