Note: CSHA = Canadian Study of Health and Aging,22 NACC = National Alzheimer’s Coordinating Center’s Uniform Data Set,25 NRI_e = net reclassification improvement for events (participants with dementia), NRI_ne = net reclassification improvement for nonevents (participants with normal cognition), NRI = total net reclassification improvement, 3MS = Modified Mini-Mental State Examination.

↵* In the training sample population (CHSA), most participants with a 3MS score of 78 or more were automatically classified as cognitively normal without further clinical evaluation, thus providing an artificial advantage to the MMSE cut-off for nonevents.