[HTML][HTML] Modeling Parkinson's disease with the alpha-synuclein protein

M Gómez-Benito, N Granado, P García-Sanz… - Frontiers in …, 2020 - frontiersin.org
Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

[HTML][HTML] Biomedical applications and bioavailability of curcumin—An updated overview

SI Sohn, A Priya, B Balasubramaniam… - Pharmaceutics, 2021 - mdpi.com
Curcumin, a yellow-colored molecule derived from the rhizome of Curcuma longa, has been
identified as the bioactive compound responsible for numerous pharmacological activities of …

[HTML][HTML] Potential role of ginger (Zingiber officinale Roscoe) in the prevention of neurodegenerative diseases

R Arcusa, D Villaño, J Marhuenda, M Cano… - Frontiers in …, 2022 - frontiersin.org
Ginger is composed of multiple bioactive compounds, including 6-gingerol, 6-shogaol, 10-
gingerol, gingerdiones, gingerdiols, paradols, 6-dehydrogingerols, 5-acetoxy-6-gingerol, 3 …

Metals associated neurodegeneration in Parkinson's disease: Insight to physiological, pathological mechanisms and management

K Raj, P Kaur, GD Gupta, S Singh - Neuroscience letters, 2021 - Elsevier
Parkinson's disease (PD) is a deliberately progressive neurological disorder, arises due to
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The …

[HTML][HTML] Cannabidiol for neurodegenerative disorders: A comprehensive review

S Bhunia, N Kolishetti, AY Arias, A Vashist… - Frontiers in …, 2022 - frontiersin.org
Despite the significant advances in neurology, the cure for neurodegenerative conditions
remains a formidable task to date. Among various factors arising from the complex etiology …

[HTML][HTML] Neurodegenerative diseases: Regenerative mechanisms and novel therapeutic approaches

R Hussain, H Zubair, S Pursell, M Shahab - Brain sciences, 2018 - mdpi.com
Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …

[HTML][HTML] Clinical features of Parkinson's disease: the evolution of critical symptoms

C Váradi - Biology, 2020 - mdpi.com
Parkinson's disease (PD) is a multi-attribute neurodegenerative disorder combining motor
and nonmotor symptoms without well-defined diagnostic clinical markers. The presence of …

iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates

AH Laperle, S Sances, N Yucer, VJ Dardov… - Nature medicine, 2020 - nature.com
Young-onset Parkinson's disease (YOPD), defined by onset at< 50 years, accounts for
approximately 10% of all Parkinson's disease cases and, while some cases are associated …

[HTML][HTML] GaborPDNet: Gabor transformation and deep neural network for Parkinson's disease detection using EEG signals

HW Loh, CP Ooi, E Palmer, PD Barua, S Dogan… - Electronics, 2021 - mdpi.com
Parkinson's disease (PD) is globally the most common neurodegenerative movement
disorder. It is characterized by a loss of dopaminergic neurons in the substantia nigra of the …

Advancement in the modelling and therapeutics of Parkinson's disease

SN Rai, P Singh - Journal of chemical neuroanatomy, 2020 - Elsevier
Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …