Rationale: Methodological sources of bias and suboptimal reporting contribute to irreproducibility
in preclinical science and may negatively affect research translation. Randomization, …

Correspondence to: Benjamin Hibbert, MD, PhD, University of Ottawa Heart Institute, 40
Ruskin Street, H-4238, Ottawa, ONT, Canada K1Y 4W7. E-mail bhibbert@ ottawaheart. ca

Purpose: Patients with advanced or recurrent invasive vulvar squamous cell carcinoma (VSCC)
have limited treatment options and a grave prognosis. Understanding the genomic …

Complete blood vessel occlusion is required for the treatment of age-related macular
degeneration (AMD). AMD is the leading cause of blindness in developed countries and current …

Background Despite a widespread shift to selective non-operative management (SNOM) for
blunt splenic trauma, there remains uncertainty regarding the role of adjuncts such as …

Objectives Obstetrics and Gynecology (Ob/Gyn) residency programs in Canada mandate
participation in scholarly research activity, yet there remains a lack of literature on trainees’ …

In this analysis of 3,396 preclinical cardiovascular studies, women were first, senior, and
both first and senior authors in 41.3%, 20.7%, and 11.0% of the studies, respectively. Female …

The developing field of nanotoxicology aims to relate the physical properties of nanomaterials
to potential risk when organisms are exposed to those materials. Regulators are …

Aims Patients often turn to the Internet for information on medical conditions. We sought to
evaluate the quality and readability of highly visible websites on overactive bladder (OAB). …

Background and Purpose— Preclinical research using animals often informs clinical trials.
However, its value is dependent on its scientific validity and reproducibility, which are, in turn, …