Importance Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease with an
unmet need for treatments that provide rapid and high levels of skin clearance and itch …

Background Systemic therapies are typically combined with topical corticosteroids for the
management of moderate-to-severe atopic dermatitis. Upadacitinib is an oral Janus kinase (…

Necrobiosis lipoidica (NL) is a rare chronic granulomatous disease that has historically been
associated with diabetes mellitus. Debate exists regarding the etiology and pathogenesis …

Disorders of hyperpigmentation and skin lightening treatments have a significant impact on
the dermatologic, physiologic, psychologic, economic, social, and cultural aspects of life. …

Background Primary (week 16) results from the ongoing phase 3, double-blind AD Up study
(NCT03568318) demonstrate a positive benefit–risk profile for upadacitinib + topical …

Levamisole is an immunomodulatory agent that was used to treat various cancers before being
withdrawn from the United States market in 2000 because of adverse effects. Levamisole …

Originating from the word “albus,” meaning white in Latin, albinism is a genetic disorder
resulting in a decrease or absence of pigmentation in the hair, eyes, and skin. 1, 2 The …

BACKGROUND: Frontal fibrosing alopecia (FFA) is a type of scarring hair loss primarily
observed in postmenopausal women and characterized by fronto-tempero-parietal hairline …

Background Acne is the most frequent adverse event associated with upadacitinib treatment
in patients with moderate-to-severe atopic dermatitis. Objective To characterize the adverse …

Fred Wise (1881-1950) and Marion Sulzberger (1895-1983) are often credited with introducing
the term atopic dermatitis to dermatology in 1933. This definition was based on atopy, a …