Background We update recommendations on 12 topics that were in the 9th edition of these
guidelines, and address 3 new topics. Methods We generate strong (Grade 1) and weak (…

Background This article addresses the treatment of VTE disease. Methods We generated
strong (Grade 1) and weak (Grade 2) recommendations based on high-quality (Grade A), …

Background The direct oral thrombin inhibitor dabigatran has a predictable anticoagulant
effect and may be an alternative therapy to warfarin for patients who have acute venous …

This chapter about treatment for venous thromboembolic disease is part of the American
College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Grade 1 …

We have previously demonstrated that a clinical model can be safely used in a management
strategy in patients with suspected pulmonary embolism (PE). We sought to simplify the …

Background Several diagnostic strategies using ultrasound imaging, measurement of D-dimer,
and assessment of clinical probability of disease have proved safe in patients with …

Most deep vein thromboses (DVTs) start in the calf, and most probably resolve spontaneously.
Thrombi that remain confined to the calf rarely cause leg symptoms or symptomatic …

Background Patients who have a first episode of venous thromboembolism in the absence
of known risk factors for thrombosis (idiopathic thrombosis) are often treated with …

Background: The low specificity of ventilation-perfusion lung scanning complicates the
management of patients with suspected pulmonary embolism. Objective: To determine the safety …

Background Dabigatran, which is administered in a fixed dose and does not require
laboratory monitoring, may be suitable for extended treatment of venous thromboembolism. …