Background Registry data on patients with type 1 diabetes mellitus who undergo pancreatic
islet transplantation indicate that only 8 percent are free of the need for insulin therapy at …

Background Islet transplantation offers the potential to improve glycemic control in a subgroup
of patients with type 1 diabetes mellitus who are disabled by refractory hypoglycemia. We …

Islet transplantation can restore endogenous β-cell function to subjects with type 1 diabetes.
Sixty-five patients received an islet transplant in Edmonton as of 1 November 2004. Their …

Islet transplantation offers the prospect of good glycemic control without major surgical risks.
After our initial report of successful islet transplantation, we now provide further data on 12 …

Clinical islet transplantation is gaining acceptance as a potential therapy, particularly for
subjects who have labile diabetes or problems with hypoglycemic awareness. The risks of the …

Objective: To evaluate the long-term efficacy of acarbose, an α-glucosidase inhibitor, in
improving glycemic control in patients with non–insulin-dependent diabetes mellitus. Design: A 1-…

Pregnancy is associated with insulin resistance. We studied insulin binding and postbinding
function in isolated adipocytes from pregnant and nonpregnant rats. We also used a primary …

To assess the mechanisms responsible for the insulin resistance associated with both normal
human pregnancy and gestational-onset diabetes, we have measured exogenous glucose …

OBJECTIVE—Type 2 diabetes is associated with defects in insulin secretion and insulin
action. Hyperglycemia may aggravate these defects, a feature known as glucose toxicity. …

Background The optimal source and amount of dietary carbohydrate for managing type 2
diabetes (T2DM) are unknown. Objective We aimed to compare the effects of altering the …