Despite over a century of research, tuberculosis remains a leading cause of infectious death
worldwide. Faced with increasing rates of drug resistance, the identification of genes that …

Despite the importance of tuberculosis as a public health problem, we know relatively little
about the molecular mechanisms used by the causative organism, Mycobacterium …

Certain pathogens, such as Mycobacterium tuberculosis, survive within the hostile intracellular
environment of a macrophage. To identify host factors required for mycobacterial entry …

The genus Mycobacterium is best known for its two major pathogenic species, M. tuberculosis
and M. leprae, the causative agents of two of the world's oldest diseases, tuberculosis and …

For decades, identifying the regions of a bacterial chromosome that are necessary for viability
has relied on mapping integration sites in libraries of random transposon mutants to find …

mariner family transposons are widespread among eukaryotic organisms. These transposons
are apparently horizontally transmitted among diverse eukaryotes and can also transpose …

Covid-19 Vaccines — A Global Public Good The editors of the Journal note that although the
rapid development of Covid-19 vaccines would appear to be a landmark success in global …

Macrophages are central to host defense against microbes, but intracellular pathogens
have evolved to evade their antimicrobial functions. Mycobacterium tuberculosis (MTB) has …

An increasing number of microbial genomes have been completely sequenced, and the
identified genes are categorized based on their homology to genes of known function. However, …

Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …