User profiles for Evan Lewis

Evan JH Lewis

University of Toronto
Verified email at utoronto.ca
Cited by 544

Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

…, B Goyal, JR Janes, GJ Laidig, ER Lewis… - Molecular cancer …, 2014 - AACR
Glutamine serves as an important source of energy and building blocks for many tumor cells.
The first step in glutamine utilization is its conversion to glutamate by the mitochondrial …

Misperceptions, the media, and the Iraq war

S Kull, C Ramsay, E Lewis - Pol. Sci. Q., 2003 - HeinOnline
The Iraq war and its aftermath have raised compelling questions about the capacity of the
executive branch to elicit public consent for the use of military force and about the role the …

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

…, M Dajee, MN Ho, J Jiang, GJ Laidig, ER Lewis… - Cancer research, 2007 - AACR
Clinical studies with bortezomib have validated the proteasome as a therapeutic target for
the treatment of multiple myeloma and non-Hodgkin's lymphoma. However, significant …

Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047)

…, J Jiang, CJ Kirk, GJ Laidig, ER Lewis… - Journal of medicinal …, 2009 - ACS Publications
Proteasome inhibition has been validated as a therapeutic modality in the treatment of
multiple myeloma and Non-Hodgkin’s lymphoma. Carfilzomib, an epoxyketone currently …

Antitumor activity of a kinesin inhibitor

R Sakowicz, JT Finer, C Beraud, A Crompton, E Lewis… - Cancer research, 2004 - AACR
Several members of the kinesin family of microtubule motor proteins play essential roles in
mitotic spindle function and are potential targets for the discovery of novel antimitotic cancer …

Economic reform in New Zealand 1984-95: The pursuit of efficiency

L Evans, A Grimes, B Wilkinson, D Teece - Journal of Economic Literature, 1996 - JSTOR
A. Overview r RIGGERED BY A constitutional and foreign exchange crisis in July 1984, New
Zealand launched into a sequence of economic reforms which David Henderson (1995), an …

MR‐guided laser interstitial thermal therapy for pediatric drug‐resistant lesional epilepsy

EC Lewis, AG Weil, M Duchowny, S Bhatia… - …, 2015 - Wiley Online Library
Objective To report the feasibility, safety, and clinical outcomes of an exploratory study of
MR ‐guided Laser Interstitial Thermal Therapy ( MR g LITT ) as a minimally invasive surgical …

Effect of omega-3 supplementation on neuropathy in type 1 diabetes: a 12-month pilot trial

EJH Lewis, BA Perkins, LE Lovblom, RP Bazinet… - Neurology, 2017 - AAN Enterprises
Objective: To test the hypothesis that 12 months of seal oil omega-3 polyunsaturated fatty
acids (ω-3 PUFA) supplementation will stop the known progression of diabetic sensorimotor …

21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function and performance in male athletes compared to olive oil …

EJH Lewis, PW Radonic, TMS Wolever… - Journal of the …, 2015 - Taylor & Francis
Full article: 21 days of mammalian omega-3 fatty acid supplementation improves aspects of
neuromuscular function and performance in male athletes compared to olive oil placebo …

Fibrin-based 3D matrices induce angiogenic behavior of adipose-derived stem cells

…, JA Rytlewski, AG Merchant, KS Dhada, EW Lewis… - Acta biomaterialia, 2015 - Elsevier
Engineered three-dimensional biomaterials are known to affect the regenerative capacity of
stem cells. The extent to which these materials can modify cellular activities is still poorly …