Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1* 0401 MHC class …
…, A Sette, AM Jevnikar, DA Bell, E Cairns - The Journal of …, 2003 - journals.aai.org
Rheumatoid arthritis (RA) is genetically associated with MHC class II molecules that contain
the shared epitope. These MHC molecules may participate in disease pathogenesis by …
the shared epitope. These MHC molecules may participate in disease pathogenesis by …
Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis
…, NA Shadick, DA Bell, E Cairns… - Arthritis & …, 2010 - Wiley Online Library
… Bell and Cairns are coinventors on a patent for the synthetic citrullinated peptide JED, which
… Bell and Cairns are coinventors on a patent for the synthetic citrullinated peptide JED, which …
… Bell and Cairns are coinventors on a patent for the synthetic citrullinated peptide JED, which …
IgA potentiates NETosis in response to viral infection
…, MA Zahoor, C Kaushic, E Cairns… - Proceedings of the …, 2021 - National Acad Sciences
IgA is the second most abundant antibody present in circulation and is enriched at mucosal
surfaces. As such, IgA plays a key role in protection against a variety of mucosal pathogens …
surfaces. As such, IgA plays a key role in protection against a variety of mucosal pathogens …
Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice
…, DM Lee, W Hueber, WH Robinson, E Cairns - The Journal of …, 2008 - rupress.org
Rheumatoid arthritis (RA) is a common autoimmune disease that afflicts the synovium of
diarthrodial joints. The pathogenic mechanisms inciting this disease are not fully characterized, …
diarthrodial joints. The pathogenic mechanisms inciting this disease are not fully characterized, …
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome
…, P Kubes, SMM Haeryfar, JK McCormick, E Cairns… - Nature medicine, 2009 - nature.com
Staphylococcal superantigens are pyrogenic exotoxins that cause massive T cell activation
leading to toxic shock syndrome and death. Despite the strong adaptive immune response …
leading to toxic shock syndrome and death. Despite the strong adaptive immune response …
Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α‐enolase and arthritis in DR4‐IE–transgenic mice
…, L Barra, N Wegner, DA Bell, E Cairns… - Arthritis & …, 2011 - Wiley Online Library
Objective To examine the hypothesis that the subset of rheumatoid arthritis (RA) characterized
by antibodies to citrullinated α‐enolase is mediated by Porphyromonas gingivalis enolase …
by antibodies to citrullinated α‐enolase is mediated by Porphyromonas gingivalis enolase …
[HTML][HTML] Bacterial Superantigens Promote Acute Nasopharyngeal Infection by Streptococcus pyogenes in a Human MHC Class II-Dependent Manner
…, I Welch, ML Baroja, M Kotb, E Cairns… - PLoS …, 2014 - journals.plos.org
Establishing the genetic determinants of niche adaptation by microbial pathogens to specific
hosts is important for the management and control of infectious disease. Streptococcus …
hosts is important for the management and control of infectious disease. Streptococcus …
Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA
…, M Li, X Huang, X Yan, R Zhong, E Cairns… - The Journal of …, 2003 - journals.aai.org
RNA interference is a mechanism of posttranscriptional gene silencing that functions in most
eukaryotic cells, including human and mouse. Specific gene silencing is mediated by short …
eukaryotic cells, including human and mouse. Specific gene silencing is mediated by short …
Antihomocitrullinated fibrinogen antibodies are specific to rheumatoid arthritis and frequently bind citrullinated proteins/peptides
…, DD Gladman, J Pope, L Barra, E Cairns - The Journal of …, 2014 - jrheum.org
Objective. Anticitrullinated protein/peptide antibodies (ACPA) are implicated in rheumatoid
arthritis (RA) pathogenesis and linked to the shared epitope (SE). Citrulline modification is …
arthritis (RA) pathogenesis and linked to the shared epitope (SE). Citrulline modification is …
Anti–citrullinated protein antibodies in unaffected first‐degree relatives of rheumatoid arthritis patients
…, S Rohekar, M Racapé, R Coles, E Cairns… - Arthritis & …, 2013 - Wiley Online Library
Objective First‐degree relatives (FDRs) of rheumatoid arthritis (RA) patients sharing genetic
and environmental risk factors for RA may represent a pre‐RA state. Since anti–cyclic …
and environmental risk factors for RA may represent a pre‐RA state. Since anti–cyclic …
