A number of clinical studies have associated acute anemia with cerebral injury in
perioperative patients. Evidence of such injury has been observed near the currently accepted …

Aims To determine whether a restrictive strategy of red blood cell (RBC) transfusion at lower
haemoglobin concentrations is inferior to a liberal strategy of RBC transfusion at higher …

Objective: Restrictive red cell transfusion is recommended to minimize risk associated with
exposure to allogeneic blood. However, perioperative anemia is an independent risk factor …

Background The effect of a restrictive versus liberal red-cell transfusion strategy on clinical
outcomes in patients undergoing cardiac surgery remains unclear. Methods In this multicenter…

A, EPO levels in patients receiving empagliflozin 10 mg daily (red circles) or placebo (blue
squares) plotted as mean±95% CIs. Adjusted differences are betweengroup differences in …

Background We reported previously that, in patients undergoing cardiac surgery who were at
moderate-to-high risk for death, a restrictive transfusion strategy was noninferior to a liberal …

Objective To compare a restrictive versus a liberal transfusion strategy in patients with
moderate to severe closed head injury following multiple trauma in 13 Canadian intensive care …

Background Despite decreasing cardiac events, perioperative beta-blockade also increases
perioperative stroke and mortality. Major bleeding and/or hypotension are independently …

This study tested the hypothesis that specific hypoxic molecules, including hypoxia-inducible
factor-1α (HIF-1α), neuronal nitric oxide synthase (nNOS), and vascular endothelial growth …

Background: Perioperative metoprolol increases postoperative stroke. Animal studies indicate
that the mechanism may be related to attenuated β 2 -adrenoreceptor-mediated cerebral …