International hospitals and healthcare facilities are facing catastrophic financial challenges
related to the COVID-19 pandemic. The American Hospital Association estimates a financial …

… & Hurley, JH Molecular mechanism of multivesicular body biogenesis by the ESCRT
complexes. Nature 464, 864–869 (2010). Reveals that ESCRT-I and ESCRT-II work together to …

The covalent modification of proteins by ubiquitination is a major regulatory mechanism of
protein degradation and quality control, endocytosis, vesicular trafficking, cell-cycle control, …

We present analytic formulae that approximate the evolution of stars for a wide range of mass
M and metallicity Z. Stellar luminosity, radius and core mass are given as a function of age, …

We present a rapid binary-evolution algorithm that enables modelling of even the most complex
binary systems. In addition to all aspects of single-star evolution, features such as mass …

ContextRising costs of medications and inequities in access have sparked calls for drug policy
reform in the United States and Canada. Control of drug expenditures by prescription cost-…

Opioid drugs act on specific receptors to modulate a wide range of physiological functions.
There are at least three types of opioid receptors, mu, delta, and kappa. Using a cDNA probe …

EU policymakers recognise that improving working conditions is crucial to achieving a better
quality of work, greater productivity and increased employment – the Lisbon objectives. In …

We present the spectrum of compact object masses: neutron stars and black holes (BHs)
that originate from single stars in different environments. In particular, we calculate the …

… Thomas Wollert and James Hurley have reconstituted MVB biogenesis using giant unilamellar
vesicles and all the ESCRT complexes. They find that ESCRT-0 is required for clustering …