In addition to differences in the pharmacodynamic response in the infant, the dose and the
pharmacokinetic processes acting upon that dose principally determine the efficacy and/or …

Cancer causes considerable morbidity and mortality across the world. Socioeconomic,
environmental, and lifestyle factors contribute to the increasing cancer prevalence, bespeaking a …

Simple Summary Breast and prostate cancers are serious public health issues that create
considerable burden to both people and healthcare systems worldwide. Cancer is a …

Dramatic developmental changes in the physiological and biochemical processes that govern
drug pharmacokinetics and pharmacodynamics occur during the first year of life. These …

Flaxseed is the richest source of the lignan secoisolariciresinol diglucoside (SDG). After
ingestion, SDG is converted to secoisolariciresinol, which is further metabolised to the …

Maturation of drug systemic clearance mechanisms during the postnatal period produces
dramatic and rapid changes in an infant’s capacity to eliminate drugs. A tentative general …

The 3,5-bis(arylidene)-4-piperidones 1 contain the 1,5-diaryl-3-oxo-1,4-pentadienyl
pharmacophore which is considered to interact at a complementary binding site in susceptible …

Plasma binding protein levels are lower in the newborn than in the adult and gradually increase
with age. At birth, human serum albumin (HSA) concentrations are close to adult levels (…

Objective: To determine the pharmacokinetics (PK) and safety of various oral doses of a
Cannabis herbal extract (CHE) containing a 1:20 ratio of Δ9-tetrahydrocannabinol (THC):…

Purpose: There is uncertainty regarding the appropriate dose of Cannabidiol (CBD) for
childhood epilepsy. We present the preliminary data of seven participants from the Cannabidiol …