Apoptosis and cancer: mutations within caspase genes

…, W Xiao, M Eshraghi, CJ Bus, K Kadkhoda… - Journal of medical …, 2009 - jmg.bmj.com
The inactivation of programmed cell death has profound effects not only on the development
but also on the overall integrity of multicellular organisms. Beside developmental …

The role of antibody testing for SARS-CoV-2: is there one?

…, MR Couturier, SJ Wong, K Kadkhoda - Journal of clinical …, 2020 - Am Soc Microbiol
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) brought
with it rapid development of both molecular and serologic assays for identification of COVID-…

Herd immunity to COVID-19: alluring and elusive

K Kadkhoda - American journal of clinical pathology, 2021 - academic.oup.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is so far the largest infectious disease catastrophe of the 21st …

Brevinin‐2R1 semi‐selectively kills cancer cells by a distinct mechanism, which involves the lysosomal‐mitochondrial death pathway

…, T Klonisch, AJ Halayko, K Kadkhoda… - Journal of cellular …, 2008 - Wiley Online Library
Brevinin‐2R is a novel non‐hemolytic defensin that was isolated from the skin of the frog
Rana ridibunda. It exhibits preferential cytotoxicity towards malignant cells, including Jurkat (T‐…

Apoptosis in liver diseases-detection and therapeutic applications

S Ghavami, M Hashemi, K Kadkhoda… - Medical science …, 2005 - diva-portal.org
The liver is continuously exposed to a large antigenic load that includes pathogens, toxins,
tumor cells and dietary antigens. Amongst the hepatitis viruses, only hepatitis B virus (HBV) …

[HTML][HTML] S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2

S Ghavami, C Kerkhoff, WJ Chazin, K Kadkhoda… - … et Biophysica Acta (BBA …, 2008 - Elsevier
A complex of two S100 EF-hand calcium-binding proteins S100A8/A9 induces apoptosis in
various cells, especially tumor cells. Using several cell lines, we have shown that S100A8/A9-…

COVID-19: an immunopathological view

K Kadkhoda - MSphere, 2020 - Am Soc Microbiol
Since its emergence in December 2019, it took only a couple of months for an outbreak of
the novel coronavirus disease 2019 (COVID-19) to be declared a pandemic by the World …

[HTML][HTML] Role of BNIP3 in TNF-induced cell death—TNF upregulates BNIP3 expression

S Ghavami, M Eshraghi, K Kadkhoda… - … et Biophysica Acta (BBA …, 2009 - Elsevier
Tumor necrosis factor alpha (TNF) is a cytokine that induces caspase-dependent (apoptotic)
and caspase-independent (necrosis-like) cell death in different cells. We used the murine …

Post‐adenoviral‐based COVID‐19 vaccines thrombosis: A proposed mechanism

K Kadkhoda - Journal of Thrombosis and Haemostasis, 2021 - jthjournal.org
There have been several reports of thrombosis and thrombocytopenia after vaccination with
the ChAdOx1 nCoV-19 vaccine (Oxford–Astra-Zeneca) and Ad26. COV2. S vaccine (…

UF-1000i™ flow cytometry is an effective screening method for urine specimens

K Kadkhoda, K Manickam, P DeGagne… - … and infectious disease, 2011 - Elsevier
This study was undertaken to evaluate the UF-1000i™ (UF) flow cytometer to count urine
constituents including bacteria. The objective was to screen urine samples and determine what …