While the antibody response to SARS-CoV-2 has been extensively studied in blood,
relatively little is known about the antibody response in saliva and its relationship to systemic …

Mapping protein–protein interactions is an invaluable tool for understanding protein function.
Here, we report the first large‐scale study of protein–protein interactions in human cells …

Protein kinases control cellular decision processes by phosphorylating specific substrates.
Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide …

Although SARS-CoV-2 infects the upper respiratory tract, we know little about the amount,
type, and kinetics of antibodies (Ab) generated in the oral cavity in response to COVID-19 …

Using functional and proteomic screens of proteins that regulate the Cdc42 GTPase, we
have identified a network of protein interactions that center around the Cdc42 RhoGAP Rich1 …

Protein kinases control cellular responses by phosphorylating specific substrates. Recent
proteome-wide mapping of protein phosphorylation sites by mass spectrometry has …

Despite the wealth of commercially available antibodies to human proteins, research is
often hindered by their inconsistent validation, their poor performance and the inadequate …

Cell-surface receptors frequently use scaffold proteins to recruit cytoplasmic targets, but the
rationale for this is uncertain. Activated receptor tyrosine kinases, for example, engage …

Most of the patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
mount a humoral immune response to the virus within a few weeks of infection, but the …

Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by
145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating …