Opioids form an important component of general anesthesia and perioperative analgesia.
Discharge opioid prescriptions are identified as a contributor for persistent opioid use and …

Background: Duration of action increases with repeated administration of neuromuscular-blocking
agents, and intraoperative use of high doses of neuromuscular-blocking agent may …

Importance Small studies and anecdotal evidence suggest marked differences in the use of
opioids after surgery internationally; however, this has not been evaluated systematically …

Background High inspiratory oxygen fraction ( F I O 2 ) may improve tissue oxygenation but
also impair pulmonary function. We aimed to assess whether the use of high intraoperative F …

… Karim S Ladha reports they are co-PI of an observational study on medical cannabis funded
by Shoppers Drug Mart. The authors report no other potential conflicts of interest in relation …

Objectives Our primary objective was to compare the utility of the Deyo-Charlson Comorbidity
Index (DCCI) and Elixhauser-van Walraven Comorbidity Index (EVCI) to predict mortality …

Background Practice guidelines for perioperative pain management recommend that multimodal
analgesic therapy should be used for all postsurgical patients. However, the proportion …

Background While persistent opioid use after surgery has been the subject of a large number
of studies, it is unknown how much variability in the definition of persistent use impacts the …

Background Although cannabis is known to have cardiovascular and psychoactive effects,
the implications of its use before surgery are currently unknown. The objective of the present …

BACKGROUND: Esmolol is an ultrashort β-1 receptor antagonist. Recent studies suggest a
role for esmolol in pain response modulation. The authors performed a meta-analysis to …