Background Coronavirus disease 2019 (Covid-19) occurs after exposure to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the …

Background: No effective oral therapy exists for early coronavirus disease 2019 (COVID-19).
Objective: To investigate whether hydroxychloroquine could reduce COVID-19 severity in …

Importance Clinicians, patients, and policy makers rely on published results from clinical
trials to help make evidence-informed decisions. To critically evaluate and use trial results, …

In 2009 we reported the fatal case of a toddler who had received codeine after adenotonsillectomy
for obstructive sleep apnea syndrome. The child was an ultra-rapid metabolizer of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral
infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and …

Background: The role of remdesivir in the treatment of patients in hospital with COVID-19
remains ill defined in a global context. The World Health Organization Solidarity randomized …

BACKGROUND: Pediatric sleep disordered breathing is often caused by hypertrophy of the
tonsils and is commonly managed by tonsillectomy. There is controversy regarding which …

Background Decreased concentration of nitric oxide has been proposed as one of the possible
cellular mechanisms of necrotising enterocolitis (NEC). Arginine can act as a substrate …

Background Persistent pulmonary hypertension in the neonate (PPHN) is associated with
high mortality. Currently, the therapeutic mainstay for PPHN consists of assisted ventilation …

Importance Complete information in a trial protocol regarding study outcomes is crucial for
obtaining regulatory approvals, ensuring standardized trial conduct, reducing research waste, …