… Lesley Behl reports receving funding from the CITF via a research grant paid to the University
of Saskatchewan, in support of the present manuscript. Patrick Brown reports receiving …

Amyloid 3 protein (Af3) is a 40-43 amino acid peptide that Is associated with plaques in the
brains of Alzheimer’s patients and is cytotoxic to cultured neurons. Using both primary central …

beta-Amyloid protein (A beta) is a member of a small group of proteins that accumulate as
amyloid deposits in various tissues. It has recently been demonstrated that the toxicity of A …

In patients with Alzheimer’s disease, hippocampal cells are among the first neuronal cells of
the brain to degenerate. Both rat primary hippocampal neurons and cells of the clonal …

The role of insulin-like growth factor 1 (IGF-1) for the treatment of neurodegenerative
disorders, such as Alzheimer's disease, has recently gained attention. The present study …

… Behl C, Widmann M, Trapp T, Holsboer F. 17-ß estradiol protects 31 Behl C, Davis JB,
Lesley … 61 Schubert D, Behl C. The expression of amyloid beta protein precur- 36 Iversen LL, …

Various neurodegenerative disorders and syndromes are associated with oxidative stress.
The deleterious consequences of excessive oxidations and the pathophysiological role of …

Two brain-derived corticotropin-releasing hormone receptors have been cloned, termed
corticotropin-releasing hormone receptors type I and type 2. Antisense oligodeoxynucleotides …

Oxidative stress-induced neuronal cell death has been implicated in different neurological
disorders and neurodegenerative diseases; one such ailment is Alzheimer’s disease. Using …

Compelling evidence shows a strong correlation between accumulation of neurotoxic β-amyloid
(Aβ) peptides and oxidative stress in the brains of patients afflicted with Alzheimer …