Purpose Anthracycline-induced cardiotoxicity (ACT) is a serious adverse drug reaction limiting
anthracycline use and causing substantial morbidity and mortality. Our aim was to identify …

Cisplatin is a widely used and effective chemotherapeutic agent, although its use is restricted
by the high incidence of irreversible ototoxicity associated with it 1 . In children, cisplatin …

Glucocorticoids (GCS) profoundly inhibit several aspects of T cell immunity largely through
inhibition of cytokine expression at the transcriptional and posttranscriptional levels. GCS …

Guidelines 976 CMAJ, September 22, 2015, 187 (13) mendations Assessment, Development
and Evaluation)(www. grade working group. org/publications/jce_series. htm) and …

Background: Immunization is regarded as one of the most significant medical achievements
of all time. Recently, increasing attention has been paid to the pain resulting from routine …

Anthracyclines are used in over 50% of childhood cancer treatment protocols 1 , but their
clinical usefulness is limited by anthracycline-induced cardiotoxicity (ACT) manifesting as …

Aims Anthracycline‐induced cardiotoxicity (ACT) occurs in 57% of treated patients and
remains an important limitation of anthracycline‐based chemotherapy. In various genetic …

Background Hair cortisol analysis is increasingly being appreciated and applied in both
research and medicine, aiding endocrinologists with diagnosis. Content We provide an …

Bronchiolitis is the most common reason for admission to hospital in the first year of life. There
is tremendous variation in the clinical management of this condition across Canada and …

Objective To systematically review evidence on genetic risk factors for carbamazepine (
CBZ )–induced hypersensitivity reactions ( HSR s) and provide practice recommendations …