Background: The impact of coronavirus disease 2019 (COVID-19) on maternal and newborn
health is unclear. We aimed to evaluate the association between severe acute respiratory …

High-throughput genomic analyses may improve outcomes in patients with advanced cancers.
MOSCATO 01 is a prospective clinical trial evaluating the clinical benefit of this approach. …

Purpose: To establish a panel of human breast cancer (HBC) xenografts in immunodeficient
mice suitable for pharmacologic preclinical assays. Experimental Design: 200 samples of …

Purpose The diagnostic test for ALK rearrangement in non–small-cell lung cancer (NSCLC)
for crizotinib treatment is currently done on tumor biopsies or fine-needle aspirations. We …

Introduction Identification of new therapeutic agents for breast cancer (BC) requires preclinical
models that reproduce the molecular characteristics of their respective clinical tumors. In …

Since the discovery in 2012 of rearranged during transfection proto-oncogene gene (RET)
rearrangements in NSCLC, at least 12 different fusion variants have been identified, with …

Obtaining representative human colon cancer cell lines from fresh tumors is technically difficult.
Using 32 tumor fragments from patients with colon cancer, the present study shows that …

Purpose Neuroblastoma is characterized by two distinct types of genetic profiles, consisting
of either numerical or segmental chromosome alterations. The latter are associated with a …

Background Advances in molecular genetics of sarcoma have enabled the identification of
type-specific aberrations. We aimed to assess the clinical effect of systematic implementation …

Importance The risk of congenital heart defects in infants of women who had preeclampsia
during pregnancy is poorly understood, despite shared angiogenic pathways in both …