Purpose: There is uncertainty regarding the appropriate dose of Cannabidiol (CBD) for
childhood epilepsy. We present the preliminary data of seven participants from the Cannabidiol …

Epilepsy is a chronic disease characterized by recurrent unprovoked seizures. Up to 30% of
children with epilepsy will be refractory to standard anticonvulsant therapy, and those with …

Patients with Leigh syndrome classically present in early childhood with developmental
regression, ataxia, and hypotonia with subsequent respiratory and brainstem dysfunction. …

Background Initial studies suggest pharmaceutical grade cannabidiol (CBD) can reduce the
frequency of convulsive seizures and lead to improvements in quality of life in children …

CMAJ| October 18, 2021| Volume 193| Issue 41 E1597 health care providers from prescribing
cannabis and prevents cannabis extracts from being placed on provincial and territorial …

Ketamine is an N-methyl-d-aspartate (NMDA) receptor antagonist that works by binding to
the phencyclidine-binding site, thereby blocking influx of cations through the NMDA receptor …

Tuberous sclerosis is a multisystem disorder that is transmitted in an autosomal dominant
fashion. It affects approximately 1 in 10,000 live births. A growing body of evidence implicates …

Medical cannabis (MC) may offer therapeutic benefits for children with complex neurological
conditions and chronic diseases. In Canada, parents, and caregivers frequently report …

Introduction Cannabis products have been used in the management of headaches in adults
and may play a role in pediatric chronic pain. Canadian pediatricians report increasing use …

Background Paroxysmal movement disorders including paroxysmal tonic upward gaze of
infancy and paroxysmal dystonia of infancy are benign but uncommon movement disorders …