[HTML][HTML] Obesity in adults: a clinical practice guideline

…, S Sockalingam, V Taylor, E Toth, L Twells, R Tytus… - Cmaj, 2020 - Can Med Assoc
This guideline update reflects substantial advances in the epidemiology, determinants,
pathophysiology, assessment, prevention and treatment of obesity, and shifts the focus of obesity …

3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial

…, J Liutkus, D O'Keefe, R Padwal, TPP Ransom, R Tytus… - The Lancet, 2017 - thelancet.com
Background Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose
metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In …

Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial

…, LA Nasi, L Oliveira, MJDEC CANTARELLI, R Tytus… - The Lancet, 2018 - thelancet.com
Background Patients with peripheral artery disease have an increased risk of cardiovascular
morbidity and mortality. Antiplatelet agents are widely used to reduce these complications. …

Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial

…, L OLIVEIRA, MJDEC CANTARELLI, R TYTUS… - The Lancet, 2018 - thelancet.com
Background Coronary artery disease is a major cause of morbidity and mortality worldwide,
and is a consequence of acute thrombotic events involving activation of platelets and …

Clinical utility of combinatorial pharmacogenomic testing in depression: A Canadian patient-and rater-blinded, randomized, controlled trial

…, BN Frey, JM Bowen, JE Tarride, R Tytus… - Translational …, 2022 - nature.com
The pharmacological treatment of depression consists of stages of trial and error, with less
than 40% of patients achieving remission during first medication trial. However, in a large, …

Immunogenicity, safety, and tolerability of V114, a 15-valent pneumococcal conjugate vaccine, in immunocompetent adults aged 18–49 years with or without risk …

…, E Janczewska, FJ Pasquel, R Tytus… - Open Forum …, 2022 - academic.oup.com
Background Adults with certain medical and behavioral factors are at increased risk for
pneumococcal disease (PD). Sequential vaccination with 13-valent pneumococcal conjugate …

Three-year follow-up of 2-dose versus 3-dose HPV vaccine

…, J Diez-Domingo, A Schilling, H Ariffin, R Tytus… - …, 2021 - publications.aap.org
METHODS: Girls received 2 (months 0 and 6 [0, 6]: n= 301; months 0 and 12 [0, 12]: n= 151)
or 3 doses (months 0, 2, and 6 [0, 2, 6]: n= 301); boys received 2 doses ([0, 6]: n= 301;[0, 12]: …

Phase 3 trial to evaluate the safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, followed by 23-valent pneumococcal …

…, E Janczewska, FJ Pasquel, R Tytus… - Human Vaccines & …, 2023 - Taylor & Francis
Immunocompetent adults with certain medical and behavioral factors are at increased risk
of pneumococcal disease. In some countries, sequential vaccination with 13-valent …

Impact of the COVID-19 pandemic on adults with type 2 diabetes care and clinical parameters in a primary care setting in Ontario, Canada: a cross-sectional study

AYY Cheng, S Harris, I Krawchenko, R Tytus… - Canadian journal of …, 2023 - Elsevier
Objectives Diabetes requires ongoing monitoring and care to prevent long-term adverse
health outcomes. In Canada, quarantine restrictions were put into place to address the …

L'obésité chez l'adulte: ligne directrice de pratique clinique

…, S Sockalingam, V Taylor, E Toth, L Twells, R Tytus… - Cmaj, 2020 - Can Med Assoc
• L’obésité est une maladie chronique complexe, évolutive et récidivante fort répandue qui
se caractérise par une accumulation anormale ou excessive de graisses corporelles (…