Purpose Anthracycline-induced cardiotoxicity (ACT) is a serious adverse drug reaction limiting
anthracycline use and causing substantial morbidity and mortality. Our aim was to identify …

Cisplatin is a widely used and effective chemotherapeutic agent, although its use is restricted
by the high incidence of irreversible ototoxicity associated with it 1 . In children, cisplatin …

Cell-free DNA (cfDNA) has become a comprehensive biomarker in the fields of non-invasive
cancer detection and monitoring, organ transplantation, prenatal genetic testing and …

Given the success of targeted agents in specific populations it is expected that some degree
of molecular biomarker testing will become standard of care for many, if not all, cancers. To …

Aim: To identify novel variants associated with anthracycline-induced cardiotoxicity and to
assess these in a genotype-guided risk prediction model. Patients & methods: Two cohorts …

Importance Pediatric cancers are epigenetic diseases; therefore, considering tumor gene
expression information is necessary for a complete understanding of the tumorigenic processes…

Background Acute lymphoblastic leukemia (ALL) is the most common malignancy in
childhood. While hepatitis is a well‐known complication during the treatment phase of ALL, the …

… S. Rod Rassekh receives research project funding from the Canadian Institutes of Health
Research and the BC Children’s Hospital Foundation to study medical cannabis in children. …

Background Despite substantial evidence supporting a pharmacogenetic approach to warfarin
therapy in adults, evidence on the importance of genetics in warfarin therapy in children …

Adverse drug reactions (ADRs) rank as one of the top ten leading causes of death and illness
in the developed world. In cancer therapy, more patients are surviving cancer than ever …