Analgesic trials pose unique scientific, ethical, and practical challenges in pediatrics. Participants
in a scientific workshop sponsored by the US Food and Drug Administration developed …

Tremendous advances have been made in pain assessment over the past quarter century.
However, assessing pain in newborn and older infants remains one of the most difficult …

Managing acute procedural pain effectively in preterm infants in the neonatal intensive care
unit remains a significant problem. The objectives of this study were to evaluate the efficacy …

Objective: Our objective was to evaluate the initial efficacy of Calmer for mitigating pain in
preterm infants. We hypothesized that, compared to babies who received a human touch–…

Purpose: Pain is prevalent and affects functioning and quality of life of children with cerebral
palsy (CP). However, pain in CP is under recognized. The International Classification of …

CMAJ| October 18, 2021| Volume 193| Issue 41 E1597 health care providers from prescribing
cannabis and prevents cannabis extracts from being placed on provincial and territorial …

In this preliminary study, it was examined whether capacity to react to external stress (acute
pain) during neonatal intensive care predicts later neuromotor development at 4 and 8 …

In this chapter, we review empirical studies evaluating the role of prenatal maternal stress in
shaping the developmental origins of self-regulation. We focus on evidence that elucidates …

Background Paediatric chronic pain was a public health emergency before the novel coronavirus
(COVID‐19) pandemic, and this problem is predicted to escalate. Pain tends to occur …

Medical cannabis (MC) may offer therapeutic benefits for children with complex neurological
conditions and chronic diseases. In Canada, parents, and caregivers frequently report …