Objective.—The clinicopathologic features of splenic metastases have seldom been
investigated. The aim of this study was to evaluate the clinical and pathological impact of splenic …

In this paper, we first introduce and define system dynamics (SD) as a method, explore its
relationship to the feedback and control systems, and then trace the history and origin of SD. …

Objective We investigated the mutational landscape of mammalian target of rapamycin (mTOR)
signalling cascade in hepatocellular carcinomas (HCCs) with chronic HBV background, …

Background and Aims Hepatitis B virus (HBV) integrations are common in hepatocellular
carcinoma (HCC). In particular, alterations of the telomerase reverse transcriptase (TERT) gene …

Background & Aims Mutational profiling of patient tumors has suggested that hepatocellular
carcinoma (HCC) development is mainly driven by loss-of-function mutations in tumor …

While pharmacological, behavioral and psychosocial treatments are available for substance
use disorders (SUDs), they are not always effective or well-tolerated. Neuromodulation (NM…

Objectives: Trauma chest radiographs may contain subtle and time-critical pathology.
Artificial intelligence (AI) may aid in accurate reporting, timely identification and worklist …

Staphylococcus aureus is a major human pathogen responsible for a wide range of clinical
infections. SaeRS is one of the two-component systems in S. aureus that modulate multiple …

Purpose This paper is about data, information, knowledge and judgment; their definitions
and their parallel cognitive dimensionalities; and it is about their implications in innovation. …

Background Current smoking cessation treatments are limited in terms of efficacy, particularly
with regards to long term abstinence. There is a large amount of evidence implicating the …