Type 1 diabetes results from the autoimmune destruction of insulin-producing β cells in the
pancreas. Genetic and, as yet undefined, environmental factors act together to precipitate …

Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β
cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Thirty years ago, a convergence of investigational observations lead to the now widely
accepted notion that type 1 diabetes results from an autoimmune destruction of insulin …

Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β cells of
the pancreas are destroyed by T lymphocytes. Recent studies have demonstrated that …

Type 1 diabetes—or, more accurately, type 1A diabetes—is thought to arise from selective
im-munologically mediated destruction of the insulin-producing β-cells in the pancreatic …

HISTORICAL MODEL OF TYPE 1 DIABETES PATHOGENESIS It may be considered
unusual to consider a period of three decades “historical.” Yet, the evolution for our …

It is widely accepted that Type 1 diabetes is a complex disease. Genetic predisposition and
environmental factors favour the triggering of autoimmune responses against pancreatic β …

Type 1 diabetes mellitus results from a T-cell mediated autoimmune destruction of the
pancreatic beta cells in genetically predisposed individuals. The knowledge of the …

In type 1 diabetes, insulin remains the mature therapeutic cornerstone; yet, the increasing
number of individuals developing type 1 diabetes (predominantly children and adolescents) …