PROLONGED EXPOSURE TO HIGHLY ACTIVE antiretroviral therapy may be associated
with adverse effects related to mitochondrial toxicity, such as hyperlactatemia. We describe a …

Nucleoside reverse-transcriptase inhibitors (NRTIs) have been associated with functional
and structural mitochondrial abnormalities, leading to several adverse events, such as …

Methods In this prospective study, arterial blood lactate levels were measured in patients
presenting with unexplained clinical symptoms. When these levels were high, functional …

Purpose: Nucleoside reverse transcriptase inhibitors (NRTIs) are associated with
mitochondrial toxicities ranging from asymptomatic hyperlactatemia to fatal lactic acidosis. It …

Background Long-term treatment with nucleoside reverse transcriptase inhibitors (NRTIs)
can induce mitochondrial dysfunction, most severely represented by lactic acidosis …

While asymptomatic hyperlactacidemia is quite a frequent phenomenon among HIV-infected
patients treated with highly active antiretroviral therapy (HAART), lactic acidosis is a rare, but …

Hyperlactatemia associated with use of nucleoside analogue reverse transcriptase inhibitors
(NRTIs) is not a single entity but a spectrum of abnormalities. The spectrum reflects varying …

Despite the impressively beneficial effects of antiretroviral medication for HIV-infected
patients, it has become increasingly evident that prolonged therapy can also have adverse …

Most (> 85%) of the 8–18.3% of HIV-infected adults who test positive for hyperlactataemia
are symptom-free [2–6]. Subclinical hyperlactataemia is characterized by lactate levels …

The prevalence, clinical presentation, and risk factors for hyperlactatemia among patients
receiving antiretroviral therapy was determined during a 1-month period for patients in the …