Trachoma: leading cause of infectious blindness =============================================== * Erica Weir * Shariq Haider * David Telio * © 2004 Canadian Medical Association or its licensors ***Background and epidemiology:*** Trachoma is a chronic keratoconjunctivitis caused by repeated infection with the ocular serovars A, B, Ba and C of *Chlamydia trachomatis*.1 The name, derived from the Greek word for “rough,” describes the appearance of the lymphoid follicles apparent with trachomatous inflammation when the upper eyelid is everted and the upper tarsal conjunctiva inspected. A single episode of *C. trachomatis* ocular infection produces a self-limiting mucopurulent conjunctivitis. Repeated infections lead to conjunctival scarring and distortion of the lid margin, which causes the eyelashes to turn inward (entropion) and repeatedly rub against the cornea (trichiasis).1 The catastrophic outcome is corneal opacification and, ultimately, blindness. Trachoma is second only to cataracts as a cause of blindness and accounts for about 15% of cases of blindness in the world. In 1997 the World Health Organization (WHO) estimated that 146 million people were actively infected, more than 10 million had trichiasis, and about 6 million were blind from corneal scarring.1,2 Active disease is most often seen in children, and women more often than men experience the visual loss that results from chronic, untreated disease, probably because of their greater direct contact with children. The root of this infectious and preventable disease is poverty. Households affected by trachoma characteristically have young children living with unsafe water and inadequate sanitation. Transmission from eye to eye is by fingers, fomites (e.g., shared towels) and flies. Once endemic in Europe and North America, trachoma has virtually been eliminated from developed countries through improvements in hygiene and sanitation. The burden currently falls on residents of sub-Saharan Africa, northern Africa and parts of the Middle East and Asia.3 ***Clinical management:*** Laboratory diagnosis is possible using culture, immunofluorescent microscopy, enzyme-linked immunosorbent assay or polymerase chain reaction. However, laboratories are generally unavailable in poor communities where trachoma is endemic, so the diagnosis is usually made clinically. WHO has developed a simplified grading system based on signs and the extent of inflammation, conjunctival thickening and scarring, trichiasis and corneal opacity (Box 1).1 ![Figure1](http://www.cmaj.ca/) [Figure1](http://www.cmaj.ca/content/170/8/1225/F1) Box 1. Trachomatous trichiasis (stage TT) can be corrected surgically through a quick and simple procedure called bilamellar tarsal rotation, which involves division of the upper eyelid tarsal plate with external rotation of the distal margin by use of 3 or 4 sutures.1,3 In patients with corneal opacification, the only possible treatment is corneal grafting, although results in cases of trachoma are usually disappointing. Patients with active infection (stages TF and TI) can be given a 6-week course of topical tetracycline therapy or a single oral dose of azithromycin. The utility of antibiotic therapy in affected individuals, however, is questionable given the risk of recurrence. In general, effective management of trachoma must also involve interventions at the community level aimed at improving water quality, access to latrines and personal hygiene, and reducing overcrowding and the density of flies in the environment. ***Prevention:*** Humans are the only reservoir for *C. trachomatis*. Thus, treatment of acute infections along with improved hygiene and sanitation should help to eliminate the disease or at least markedly reduce its frequency. In 1997 WHO founded the Alliance for the Global Elimination of Trachoma, whose aim is to eradicate the disease by the year 2020.2,3 WHO is currently working with member states to implement its SAFE strategy (***s***urgery, ***a***ntibiotic treatment, ***f***acial hygiene and ***e***nvironmental change) in affected communities. The effort has been supported and propelled by Pfizer Inc. through its donation of azithromycin and by the Edna McConnell Clark Foundation through the establishment of the International Trachoma Initiative charity.3,4 To date, more than 55 000 lid surgeries have been performed and more than 6 million doses of azithromycin distributed. **Erica Weir** *CMAJ* **Shariq Haider** Division of Infectious Diseases McMaster University Medical Centre Hamilton, Ont. **David Telio** Faculty of Medicine University of Toronto Toronto, Ont. ## References 1. 1. Mabey DC, Solomon AW, Foster A. Trachoma. Lancet 2003;362:223-9. 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