Review
Open Access
The use and impact of monoclonal antibody biologics during pregnancy
Anne Pham-Huy, Karina A. Top, Cora Constantinescu, Cynthia H. Seow and Darine El-Chaâr
CMAJ July 26, 2021 193 (29) E1129-E1136; DOI: https://doi.org/10.1503/cmaj.202391
Anne Pham-Huy
Division of Infectious Diseases, Immunology and Allergy (Pham-Huy), Children’s Hospital of Eastern Ontario; Faculty of Medicine (Pham-Huy), University of Ottawa, Ottawa, Ont.; IWK Health Centre, Division of Infectious Diseases, Canadian Center for Vaccinology (Top), Halifax, NS; University of Calgary Faculty of Medicine, Division of Pediatric Infectious Diseases (Constantinescu); Division of Gastroenterology and Hepatology (Seow), Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alta.; OHRI OMNI Research Group (El-Chaâr), Clinical Epidemiology Program; Department of Obstetrics, Gynecology and Newborn Care (El-Chaâr), Ottawa Hospital, Ottawa, Ont.
MDKarina A. Top
Division of Infectious Diseases, Immunology and Allergy (Pham-Huy), Children’s Hospital of Eastern Ontario; Faculty of Medicine (Pham-Huy), University of Ottawa, Ottawa, Ont.; IWK Health Centre, Division of Infectious Diseases, Canadian Center for Vaccinology (Top), Halifax, NS; University of Calgary Faculty of Medicine, Division of Pediatric Infectious Diseases (Constantinescu); Division of Gastroenterology and Hepatology (Seow), Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alta.; OHRI OMNI Research Group (El-Chaâr), Clinical Epidemiology Program; Department of Obstetrics, Gynecology and Newborn Care (El-Chaâr), Ottawa Hospital, Ottawa, Ont.
MDCora Constantinescu
Division of Infectious Diseases, Immunology and Allergy (Pham-Huy), Children’s Hospital of Eastern Ontario; Faculty of Medicine (Pham-Huy), University of Ottawa, Ottawa, Ont.; IWK Health Centre, Division of Infectious Diseases, Canadian Center for Vaccinology (Top), Halifax, NS; University of Calgary Faculty of Medicine, Division of Pediatric Infectious Diseases (Constantinescu); Division of Gastroenterology and Hepatology (Seow), Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alta.; OHRI OMNI Research Group (El-Chaâr), Clinical Epidemiology Program; Department of Obstetrics, Gynecology and Newborn Care (El-Chaâr), Ottawa Hospital, Ottawa, Ont.
MDCynthia H. Seow
Division of Infectious Diseases, Immunology and Allergy (Pham-Huy), Children’s Hospital of Eastern Ontario; Faculty of Medicine (Pham-Huy), University of Ottawa, Ottawa, Ont.; IWK Health Centre, Division of Infectious Diseases, Canadian Center for Vaccinology (Top), Halifax, NS; University of Calgary Faculty of Medicine, Division of Pediatric Infectious Diseases (Constantinescu); Division of Gastroenterology and Hepatology (Seow), Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alta.; OHRI OMNI Research Group (El-Chaâr), Clinical Epidemiology Program; Department of Obstetrics, Gynecology and Newborn Care (El-Chaâr), Ottawa Hospital, Ottawa, Ont.
MBBSDarine El-Chaâr
Division of Infectious Diseases, Immunology and Allergy (Pham-Huy), Children’s Hospital of Eastern Ontario; Faculty of Medicine (Pham-Huy), University of Ottawa, Ottawa, Ont.; IWK Health Centre, Division of Infectious Diseases, Canadian Center for Vaccinology (Top), Halifax, NS; University of Calgary Faculty of Medicine, Division of Pediatric Infectious Diseases (Constantinescu); Division of Gastroenterology and Hepatology (Seow), Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alta.; OHRI OMNI Research Group (El-Chaâr), Clinical Epidemiology Program; Department of Obstetrics, Gynecology and Newborn Care (El-Chaâr), Ottawa Hospital, Ottawa, Ont.
MD![Loading Loading](https://www.cmaj.ca/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif)
Related Articles
- Pham-Huy, A., Top, K. A., Constantinescu, C., Seow, C. H., & El-Chaâr, D. (2021). Utilisation et incidence des agents biologiques à base d’anticorps monoclonaux durant la grossesse. CMAJ, 193(39), E1537-E1544. Accessed August 12, 2024. https://doi.org/10.1503/cmaj.202391-f.
In this issue
Article tools
Respond to this article
The use and impact of monoclonal antibody biologics during pregnancy
Anne Pham-Huy, Karina A. Top, Cora Constantinescu, Cynthia H. Seow, Darine El-Chaâr
CMAJ Jul 2021, 193 (29) E1129-E1136; DOI: 10.1503/cmaj.202391
Jump to section
- Article
- What evidence and guidance exists to support prescriptions of biologics during pregnancy?
- To what degree are biologics transferred to the fetus and which are detectable at birth?
- What are the potential adverse outcomes associated with the use of biologics during pregnancy?
- Can a patient taking biologics receive immunizations during pregnancy?
- What are the effects on the infant of in utero exposure to biologics?
- Should patients taking biologics continue breastfeeding?
- Should infants exposed to biologics be immunized?
- How should the biologic-exposed infant be cared for?
- What are current knowledge gaps?
- Conclusion
- Footnotes
- References
- Figures & Tables
- Responses
- Metrics