Original Articles
Effect of a fixed-ratio (1:1:1) transfusion protocol versus laboratory-results-guided transfusion in patients with severe trauma: a randomized feasibility trial
Bartolomeu Nascimento, Jeannie Callum, Homer Tien, Gordon Rubenfeld, Ruxandra Pinto, Yulia Lin and Sandro Rizoli
CMAJ July 15, 2013 cmaj.121986; DOI: https://doi.org/10.1503/cmaj.121986
Bartolomeu Nascimento
The Departments of General Surgery (Nascimento) and Trauma and Critical Care (Rubenfeld), the Division
of General Surgery (Tien), and the Trauma, Emergency and Critical Care Program (Pinto), Sunnybrook Health Sciences
Centre, University of Toronto; the Department of Laboratory Medicine and Pathobiology (Callum, Lin), University
of Toronto; the Department of Clinical Pathology (Callum, Lin), Sunnybrook Health Sciences Centre; the Canadian
Forces Health Services (Tien); and the Departments of Surgery and Critical Care Medicine (Rizoli), St. Michael's
Hospital, University of Toronto, Toronto, Ont.
Jeannie Callum
The Departments of General Surgery (Nascimento) and Trauma and Critical Care (Rubenfeld), the Division
of General Surgery (Tien), and the Trauma, Emergency and Critical Care Program (Pinto), Sunnybrook Health Sciences
Centre, University of Toronto; the Department of Laboratory Medicine and Pathobiology (Callum, Lin), University
of Toronto; the Department of Clinical Pathology (Callum, Lin), Sunnybrook Health Sciences Centre; the Canadian
Forces Health Services (Tien); and the Departments of Surgery and Critical Care Medicine (Rizoli), St. Michael's
Hospital, University of Toronto, Toronto, Ont.
Homer Tien
The Departments of General Surgery (Nascimento) and Trauma and Critical Care (Rubenfeld), the Division
of General Surgery (Tien), and the Trauma, Emergency and Critical Care Program (Pinto), Sunnybrook Health Sciences
Centre, University of Toronto; the Department of Laboratory Medicine and Pathobiology (Callum, Lin), University
of Toronto; the Department of Clinical Pathology (Callum, Lin), Sunnybrook Health Sciences Centre; the Canadian
Forces Health Services (Tien); and the Departments of Surgery and Critical Care Medicine (Rizoli), St. Michael's
Hospital, University of Toronto, Toronto, Ont.
Gordon Rubenfeld
The Departments of General Surgery (Nascimento) and Trauma and Critical Care (Rubenfeld), the Division
of General Surgery (Tien), and the Trauma, Emergency and Critical Care Program (Pinto), Sunnybrook Health Sciences
Centre, University of Toronto; the Department of Laboratory Medicine and Pathobiology (Callum, Lin), University
of Toronto; the Department of Clinical Pathology (Callum, Lin), Sunnybrook Health Sciences Centre; the Canadian
Forces Health Services (Tien); and the Departments of Surgery and Critical Care Medicine (Rizoli), St. Michael's
Hospital, University of Toronto, Toronto, Ont.
Ruxandra Pinto
The Departments of General Surgery (Nascimento) and Trauma and Critical Care (Rubenfeld), the Division
of General Surgery (Tien), and the Trauma, Emergency and Critical Care Program (Pinto), Sunnybrook Health Sciences
Centre, University of Toronto; the Department of Laboratory Medicine and Pathobiology (Callum, Lin), University
of Toronto; the Department of Clinical Pathology (Callum, Lin), Sunnybrook Health Sciences Centre; the Canadian
Forces Health Services (Tien); and the Departments of Surgery and Critical Care Medicine (Rizoli), St. Michael's
Hospital, University of Toronto, Toronto, Ont.
Yulia Lin
The Departments of General Surgery (Nascimento) and Trauma and Critical Care (Rubenfeld), the Division
of General Surgery (Tien), and the Trauma, Emergency and Critical Care Program (Pinto), Sunnybrook Health Sciences
Centre, University of Toronto; the Department of Laboratory Medicine and Pathobiology (Callum, Lin), University
of Toronto; the Department of Clinical Pathology (Callum, Lin), Sunnybrook Health Sciences Centre; the Canadian
Forces Health Services (Tien); and the Departments of Surgery and Critical Care Medicine (Rizoli), St. Michael's
Hospital, University of Toronto, Toronto, Ont.
Sandro Rizoli
The Departments of General Surgery (Nascimento) and Trauma and Critical Care (Rubenfeld), the Division
of General Surgery (Tien), and the Trauma, Emergency and Critical Care Program (Pinto), Sunnybrook Health Sciences
Centre, University of Toronto; the Department of Laboratory Medicine and Pathobiology (Callum, Lin), University
of Toronto; the Department of Clinical Pathology (Callum, Lin), Sunnybrook Health Sciences Centre; the Canadian
Forces Health Services (Tien); and the Departments of Surgery and Critical Care Medicine (Rizoli), St. Michael's
Hospital, University of Toronto, Toronto, Ont.