PT  - JOURNAL ARTICLE
AU  - Hardy, G.
AU  - Padfield, C. J.
AU  - Chadwick, P.
AU  - Partington, M. W.
TI  - Typhoid outbreak in Kingston, Ont: experience with high-dose oral ampicillin
DP  - 1977 Apr 09
TA  - Canadian Medical Association Journal
PG  - 761--764
VI  - 116
IP  - 7
4099  - http://www.cmaj.ca/content/116/7/761.short
4100  - http://www.cmaj.ca/content/116/7/761.full
SO  - CMAJ1977 Apr 09; 116
AB  - Twenty-four children contracted typhoid fever at a summer camp near Kingston, Ont. Six were treated with chloramphenicol alone and 15 with high doses of ampicillin (300 mg/kg-d) by mouth. Ampicillin in this dosage was well tolerated except in three children in whom severe urticarial rashes developed and two who had significant diarrhea. However, high-dose oral ampicillin therapy had no advantage over that with lower doses or over chloramphenicol as judged by the rate of defervescence after the start of treatment, the rate of clinical relapse and the frequency of excretion of Salmonella typhi during convalescence.