RT Journal Article
SR Electronic
T1 Decreased population of Leu-7+ natural killer cells in lymph nodes of homosexual men with AIDS-related persistent lymphadenopathy
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 141
OP 144
VO 132
IS 2
A1 Jothy, S.
A1 Gilmore, N.
A1 El'Gabalawy, H.
A1 Prchal, J.
YR 1985
UL http://www.cmaj.ca/content/132/2/141.abstract
AB Natural killer (NK) cells were studied in the lymph nodes of homosexual men with the persistent lymphadenopathy syndrome (PLS) and other signs of the disease complex related to the acquired immune deficiency syndrome (AIDS). The NK cells were identified by their Leu-7+ phenotype and enumerated in frozen sections of lymph nodes in conjunction with the quantification of T-lymphocyte subsets. Lymph nodes from patients with AIDS-related PLS contained 91% and 81% fewer NK cells than normal lymph nodes and lymph nodes from patients with non-AIDS-related hyperplastic lymphadenopathy respectively. This decrease in NK cells in PLS is consistent with the immune dysregulation leading to persistent infection and neoplasia in AIDS.