RT Journal Article
SR Electronic
T1 Vancomycin-induced neutropenia
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 39
OP 40
VO 132
IS 1
A1 Mackett, R. L.
A1 Guay, D. R.
YR 1985
UL http://www.cmaj.ca/content/132/1/39.abstract
AB Although rare, neutropenia associated with long-term vancomycin therapy may occur. A 67-year-old woman with cellulitis and sepsis caused by Staphylococcus aureus was treated initially with cefazolin. Despite in-vitro susceptibility of the organism to this drug, the patient remained febrile, and therapy was changed to vancomycin. On day 17 of therapy with this medication neutropenia was noted; it progressed over the next 3 days, and therapy with the drug was stopped. A rise in the neutrophil count occurred within 5 days of discontinuation. Periodic monitoring of the leukocyte count during longterm vancomycin therapy is recommended.