PT  - JOURNAL ARTICLE
AU  - Antoniou, Tony
AU  - Weisdorf, Thea
AU  - Gough, Kevin
TI  - Symptomatic hyperlactatemia in an HIV-positive patient: a case report and discussion
DP  - 2003 Jan 21
TA  - Canadian Medical Association Journal
PG  - 195--198
VI  - 168
IP  - 2
4099  - http://www.cmaj.ca/content/168/2/195.short
4100  - http://www.cmaj.ca/content/168/2/195.full
SO  - CMAJ2003 Jan 21; 168
AB  - PROLONGED EXPOSURE TO HIGHLY ACTIVE antiretroviral therapy may be associated with adverse effects related to mitochondrial toxicity, such as hyperlactatemia. We describe a case of symptomatic hyperlactatemia in an HIV-positive patient to illustrate the subtle clinical symptoms and abnormal laboratory test results associated with this condition. We also review the pathophysiology, prevalence, spectrum and management of disturbances in lactate homeostasis induced by nucleoside reverse transcriptase inhibitors.