PT  - JOURNAL ARTICLE
AU  - Humphries, Karin H.
AU  - Gill, Sabrina
TI  - Risks and benefits of hormone replacement therapy: The evidence speaks
DP  - 2003 Apr 15
TA  - Canadian Medical Association Journal
PG  - 1001--1010
VI  - 168
IP  - 8
4099  - http://www.cmaj.ca/content/168/8/1001.short
4100  - http://www.cmaj.ca/content/168/8/1001.full
SO  - CMAJ2003 Apr 15; 168
AB  - UNTIL RECENTLY, OBSERVATIONAL STUDIES suggested a decreased risk of cardiovascular disease, osteoporotic fractures, cognitive decline and colon cancer with the use of hormone replacement therapy (HRT). Recent randomized controlled trials have failed to show a protective effect of HRT in reducing the risk of coronary artery disease and instead have revealed an increased risk of heart disease, stroke, invasive breast cancer and venous thromboembolism, but a decreased risk of colorectal cancer and osteoporotic fractures. In this article we review the current evidence of the risks and benefits of HRT.