RT Journal Article
SR Electronic
T1 Risks and benefits of hormone replacement therapy: The evidence speaks
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 1001
OP 1010
VO 168
IS 8
A1 Humphries, Karin H.
A1 Gill, Sabrina
YR 2003
UL http://www.cmaj.ca/content/168/8/1001.abstract
AB UNTIL RECENTLY, OBSERVATIONAL STUDIES suggested a decreased risk of cardiovascular disease, osteoporotic fractures, cognitive decline and colon cancer with the use of hormone replacement therapy (HRT). Recent randomized controlled trials have failed to show a protective effect of HRT in reducing the risk of coronary artery disease and instead have revealed an increased risk of heart disease, stroke, invasive breast cancer and venous thromboembolism, but a decreased risk of colorectal cancer and osteoporotic fractures. In this article we review the current evidence of the risks and benefits of HRT.