PT  - JOURNAL ARTICLE
AU  - Robinson, G. E.
TI  - Premenstrual syndrome: current knowledge and management
DP  - 1989 Mar 15
TA  - Canadian Medical Association Journal
PG  - 605--611
VI  - 140
IP  - 6
4099  - http://www.cmaj.ca/content/140/6/605.short
4100  - http://www.cmaj.ca/content/140/6/605.full
SO  - CMAJ1989 Mar 15; 140
AB  - Premenstrual syndrome (PMS) has become a popular self-diagnosis. Faulty research has led to confusion about the diagnosis, epidemiologic features, causes and treatment of this disorder. There is no proof that the premenstrual period is a time of increased violence. An association between menstrually related mood disorders and other psychiatric illness is also unproven. Despite many theories no definitive cause of PMS has been established, and controlled studies of various treatments have failed to find a universally effective approach. Conservative measures involving support, diet and exercise seem to help in most cases. The use of alprazolam and mefenamic acid may help some women. Rectal or vaginal progesterone therapy has been proven ineffective and should not be used.