RT Journal Article SR Electronic T1 Use of high-dosage trimethoprim-sulfamethoxazole in sinusitis JF Canadian Medical Association Journal JO CMAJ FD Canadian Medical Association SP 89 OP 90 VO 112 IS 13 A1 Whitehead, E. YR 1975 UL http://www.cmaj.ca/content/112/13/89.abstract AB The combination trimethoprim-sulfamethoxazole was given in high dosage (four tablets twice daily) for either 2 or 5 days to 20 patients with sinusitis diagnosed on clinical grounds. In 11 the infection was improved or cured. Swabs cultured from 18 patients of the series produced no growth in 8. The organisms most likely to be isolated are Hemophilus influenzae and Diplococcus pneumoniae.