PT  - JOURNAL ARTICLE
AU  - Rorstad, O.
AU  - Urtasun, R.
AU  - Watanabe, M.
TI  - Variation in response to dexamethasone of a patient with Cushing's syndrome
DP  - 1976 Nov 06
TA  - Canadian Medical Association Journal
PG  - 878--879
VI  - 115
IP  - 9
4099  - http://www.cmaj.ca/content/115/9/878.short
4100  - http://www.cmaj.ca/content/115/9/878.full
SO  - CMAJ1976 Nov 06; 115
AB  - A patient with Cushing's syndrome due to a nonresectable chromophobe adenoma underwent external irradiation of the hypothalamic-pituitary area. The signs of Cushing's syndrome ameliorated subsequently but recurred eventually, necessitating bilateral adrenalectomy 30 months after initial presentation. Response to dexamethasone suppression testing on four occasions varied greatly. These results may reflect alterations in sensitivity of the tumour or the hypothalamic-pituitary axis to feedback inhibition by glucocorticoids.