PT  - JOURNAL ARTICLE
AU  - Cockcroft, D. W.
AU  - Donevan, R. E.
AU  - Copland, G. M.
AU  - Ibbott, J. W.
TI  - Miliary tuberculosis presenting with hyponatremia and thrombocytopenia
DP  - 1976 Nov 06
TA  - Canadian Medical Association Journal
PG  - 871--873
VI  - 115
IP  - 9
4099  - http://www.cmaj.ca/content/115/9/871.short
4100  - http://www.cmaj.ca/content/115/9/871.full
SO  - CMAJ1976 Nov 06; 115
AB  - A 74-year-old woman with miliary tuberculosis had moderately severe hyponatremia due to inappropriate secretion of antidiuretic hormone (SIADH) and very severe thrombocytopenia without other hematologic abnormalities. She was treated with isoniazid, rifampin, ethambutol, prednisone, vincristine and fluid restriction and recovered completely. The SIADH may have been a response by the posterior pituitary to a decrease in intravascular volume resulting from the extensive pulmonary disease or associated hypoxia, or the tuberculous lung may have released ADH or an ADH-like substance. The thrombocytopenia may have resulted from a direct or indirect toxic effect of infection or, less likely, the tuberculosis may have activated latent idiopathic thrombocytopenic purpura.