PT  - JOURNAL ARTICLE
AU  - Osborn, D. C.
AU  - Fox, R. A.
AU  - Fernandez, L. A.
AU  - MacSween, J. M.
AU  - Langley, G. R.
TI  - Cytotoxic lymphocytes in infectious mononucleosis
DP  - 1976 Dec 04
TA  - Canadian Medical Association Journal
PG  - 1118--1119
VI  - 115
IP  - 11
4099  - http://www.cmaj.ca/content/115/11/1118.short
4100  - http://www.cmaj.ca/content/115/11/1118.full
SO  - CMAJ1976 Dec 04; 115
AB  - Seven patients with a clinical diagnosis of infectious mononucleosis (IM) and detectable heterophil antibodies were found to have peripheral blood lymphocytes that were cytotoxic for lymphoid cells containing Epstein-Barr virus from a patient with Burkitt's lymphoma. The cytotoxic lymphocytes persisted in the peripheral circulation for up to 45 days. Patients who had had IM 1 to 5 years previously lacked such cytotoxic lymphocytes. Patients who had signs and symptoms of IM but no detectable heterophil antibodies lacked cytotoxic lymphocytes. The lymphocytes of one patient with IM showed progressive diminution of cytotoxic ability after prednisone treatment.