PT  - JOURNAL ARTICLE
AU  - Spence, L.
AU  - Fauvel, M.
TI  - Detection of core antibody in hepatitis B infection
DP  - 1976 Nov 20
TA  - Canadian Medical Association Journal
PG  - 998--1000
VI  - 115
IP  - 10
4099  - http://www.cmaj.ca/content/115/10/998.short
4100  - http://www.cmaj.ca/content/115/10/998.full
SO  - CMAJ1976 Nov 20; 115
AB  - Hepatitis B core antigen (HBcAg) is found on the decoated Dane particle and on a morphologically similar particle detected mainly in the nucleus of hepatocytes of patients with hepatitis B. HBcAg prepared from the liver of a chimpanzee infected with hepatitis B virus was used to test human serum for core antibody (anti-HBc) by complement fixation. Anti-HBc was found in serum collected from patients with hepatitis B in both the acute and convalescent stages, from carriers of hepatitis B surface antigen (HBsAg) and from patients with chronic liver or renal disease who were carriers of HBsAg. It was not found in patients with hepatitis A or infectious mononucleosis, or in healthy persons who were not carriers of HBsAg.