PT  - JOURNAL ARTICLE
AU  - Wilkins, G. E.
TI  - Hypertension, hypokalemia, hyporeninemia and severe target organ damage
DP  - 1976 Feb 07
TA  - Canadian Medical Association Journal
PG  - 241--243
VI  - 114
IP  - 3
4099  - http://www.cmaj.ca/content/114/3/241.short
4100  - http://www.cmaj.ca/content/114/3/241.full
SO  - CMAJ1976 Feb 07; 114
AB  - A 51-year-old woman with a 20-year history of severe hypertension and target organ damage had nondiuretic hypokalemia, kaluresis, suppressed plasma renin activity and elevated urinary excretion of aldosterone. Renal arteriography demonstrated unilateral renal artery stenosis secondary to fibromuscular hyperplasia. Blood pressure responded only minimally to almost all antihypertensive agents. Spironolactone, 300 to 400 mg/d, produced distinct improvement in blood pressure, which was maintained for 13 months.