RT Journal Article
SR Electronic
T1 Disseminated histoplasmosis and necrotizing vasculitis
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 140
OP 141
VO 114
IS 2
A1 Small, P.
A1 Levitt, P.
YR 1976
UL http://www.cmaj.ca/content/114/2/140.abstract
AB A 74-year-old man with congestive heart failure was found to have Histoplasma capsulatum in a lesion of the right nasal septum. His initial treatment with amphotericin B was inadequate because of severe intolerance to the drug. Three months after initial presentation H. capsulatum was detected in his blood and bone marrow. Slightly elevated purpuric lesions on the arms, lower legs and trunk showed the typical features of necrotizing vasculitis. Cutaneous anergy was reversed after treatment with transfer factor. Skin involvement in disseminated histoplasmosis is unusual and there are no previous reports of vasculitis associated with this infection.