PT - JOURNAL ARTICLE AU - Allard, Jacques AU - Hébert, Réjean AU - Rioux, Maryse AU - Asselin, Johannne AU - Voyer, Louis TI - Efficacy of a clinical medication review on the number of potentially inappropriate prescriptions prescribed for community-dwelling elderly people DP - 2001 May 01 TA - Canadian Medical Association Journal PG - 1291--1296 VI - 164 IP - 9 4099 - http://www.cmaj.ca/content/164/9/1291.short 4100 - http://www.cmaj.ca/content/164/9/1291.full SO - CMAJ2001 May 01; 164 AB - Background: The administration of many drugs concurrently to elderly patients is a well-known problem in geriatrics and involves numerous risks. One way to reduce polypharmacy is to provide information to physicians in order to modify their prescribing practices. The main objective of this study was to evaluate the impact of an intervention program that targeted physicians with the aim of reducing the number of potentially inappropriate prescriptions (PIPs) given to elderly patients. Methods: A randomized controlled trial was carried out among community-dwelling elderly people in Sherbrooke, Que. The participants were 266 patients over 75 years of age (experimental group: n = 136, control group: n = 130). A team comprising 2 physicians, a pharmacist and a nurse reviewed the list of drugs and the diagnoses of a subgroup of the experimental group in a case conference. Suggestions were formulated and mailed to the patients' physicians together with relevant scientific documentation justifying the recommendations. The main outcome measure was the number of PIPs. Results: The mean number of PIPs per patient declined by 0.24 in the experimental group (n = 127) and by 0.15 in the control group (n = 116). The decline in PIPs was even larger in the experimental group that had case conferences (n = 80), in which the mean number of PIPs per patient declined by 0.31. However, this difference between the experimental group and the control group was not statistically significant in the intent-to-treat analysis. The number of drugs prescribed was not modified by the intervention, nor were the results of the global assessment of the patients' drug profiles. Interpretation: This study suggests that the intervention program had no effect on the prescribing of PIPs.