PT  - JOURNAL ARTICLE
AU  - Spence, J. D.
AU  - Wong, D. G.
AU  - Melendez, L. J.
AU  - Nichol, P. M.
AU  - Brown, J. D.
TI  - Increased prevalence of mitral valve prolapse in patients with migraine
DP  - 1984 Dec 15
TA  - Canadian Medical Association Journal
PG  - 1457--1460
VI  - 131
IP  - 12
4099  - http://www.cmaj.ca/content/131/12/1457.short
4100  - http://www.cmaj.ca/content/131/12/1457.full
SO  - CMAJ1984 Dec 15; 131
AB  - Patients with classic migraine (69 women and 31 men) selected randomly from a practice list of over 1000 were matched for age, sex and neighbourhood with 100 people who did not have headache problems, and both groups underwent M-mode and two-dimensional echocardiography and clinical examination by cardiologists blinded to the subjects' clinical status. The mean ages were 34.9 +/- 11.3 years for the migraine group and 33.1 +/- 9.9 years for the control group. Definite and possible mitral valve prolapse (MVP), diagnosed according to predefined echocardiographic criteria, were found about twice as often in the migraine group as in the control group (in 15 v. 7 and 16 v. 8 patients respectively); the echocardiograms were definitely normal in 69 migraine patients and 85 controls (chi 2 = 8.39, p less than 0.025). Altogether 25% of the migraine group and 11% of the control group had evidence of MVP from a combination of the echocardiographic and auscultatory findings (chi 2 = 5.72, p less than 0.025). The odds ratio was 2.7, with 95% confidence limits of 1.17 and 6.29. The association between migraine and MVP has implications for the understanding of platelet abnormalities and episodes of cerebral ischemia occurring in both these conditions.