RT Journal Article
SR Electronic
T1 Management of pheochromocytoma during pregnancy
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 371
OP 375
VO 116
IS 4
A1 Leak, D.
A1 Carroll, J. J.
A1 Robinson, D. C.
A1 Ashworth, E. J.
YR 1977
UL http://www.cmaj.ca/content/116/4/371.abstract
AB To reduce the high maternal and fetal mortality in pheochromocytoma of pregnancy, therapy is advocated with phenoxybenzamine and propranolol to obtain adequate alpha- and beta-adrenergic receptor blockade. In early pregnancy control of symptoms may be difficult, but the patient may be carried to term with such medical therapy. Delivery should be by cesarean section before the onset of labour, with, if possible, simultaneous removal of the tumour. Additional preoperative preparation with phenoxybenzamine and propranolol and careful intraoperative management are essential. During her third pregnancy a 29-year-old woman was found to have a pheochromocytoma of the left adrenal gland. After the medical therapy and preparation described, the infant was delivered by cesarean section and the mother's left adrenal gland excised. Eight-year follow-up, including during a fourth pregnancy, showed no recurrence of tumour in the mother and only mild hypertension. The infant developed normally.