Canadian Network for Mood and Anxiety Treatments guidelines for neurostimulation (51)
| Treatment | Overall recommendation | Acute efficacy data | Relapse prevention data | Safety and tolerability data |
|---|---|---|---|---|
| Electroconvulsive therapy | First-line therapy for major depressive episode with psychosis or suicidal ideation; second-line therapy for treatment-resistant populations | Level 1* | Level 1* | Level 2† |
| Repetitive transcranial magnetic stimulation | Second-line therapy | Level 1* | Level 3‡ | Level 1* |
| Deep brain stimulation | Investigational | Level 3‡ | Level 3‡ | Level 3‡ |
↵* Level 1 data: > 2 randomized controlled trials and/or meta-analysis with narrow confidence interval.
↵† Level 2 data: > 1 randomized controlled trial and/or meta-analysis with wide confidence intervals.
↵‡ Level 3 data: Nonrandomized, controlled prospective studies, case series or retrospective studies.