Table 1:

Maternal and pregnancy-related characteristics

CharacteristicNo. (%)*
NSAID exposure†No NSAID exposure
n = 60 962
Nonselective COX inhibitors
n = 4 424		COX-2 selective inhibitors
n = 71
Hypercoagulation disease1 (0.02)
p = 0.8		0 (0)
p = 0.9		17 (0.02)
In vitro fertilization100 (2.3)
p < 0.001		0 (0)
p = 0.3		847 (1.4)
Presence of an intrauterine device16 (0.4)
p = 0.2		0 (0)
p = 0.7		159 (0.3)
Tobacco use78 (1.8)
p = 0.04		0 (0)
p = 0.3		850 (1.4)
Inflammatory disease8 (0.2)
p = 0.06		2 (2.8)
p < 0.001		56 (0.1)
Hypothyroidism88 (2.0)
p = 0.02		1 (1.4)
p = 0.9		943 (1.5)
Obesity24 (0.5)
p = 0.6		0 (0)
p > 0.9		287 (0.47)
Mother’s age, yr, mean ± SD30.2 ± 5.8
p < 0.001		33.1 ± 5.8
p < 0.001		28.9 ± 5.8
Ethnic group‡
 Bedouin2 802 (63.3)43 (60.6)38 904 (63.8)
 Jewish1 622 (36.7)
p = 0.5		28 (39.4)
p = 0.6		22 058 (36.2)

  • Note: COX = cyclooxygenase, NSAID = nonsteroidal anti-inflammatory drug, SD = standard deviation.

  • ↵* Unless otherwise indicated.

  • ↵† Each exposure group was compared with the unexposed group.

  • ↵‡ Determined from information in the administrative computerized databases.