Results of interventions to improve symptoms and function, from baseline to study completion
| Variable | Glare et al. (23) | Del Fabbro et al. (24) | Chasen et al. (25) | Gagnon et al. (26) |
|---|---|---|---|---|
| General symptom burden | ||||
| ESAS* | NR | |||
| Anxiety | NR | Improved§ | Improved§ | |
| Depression | NR | Improved§ | Improved§ | |
| Well-being | Improved§ | Improved§ | Improved§ | |
| Tiredness | Improved§ | Improved§ | Improved§ | |
| Nutrition | ||||
| Appetite | Improved¶ | Improved¶ | Improved¶ | Improved¶ |
| Weight change | Improved¶ | Improved¶ | Improved¶ | Improved¶ |
| Quality of life† | Improved§ | NR | Improved§ | Improved§ |
| Fatigue‡ | ||||
| General fatigue | Improved§ | NR | Improved§ | Improved§ |
| Function | NR | |||
| Six-minute walk test | Improved§ | Improved§ | Improved§ | |
| Patients assessed at 2-mo follow-up, % | 58 | NR | 58 | 70 |
Note: ESAS = Edmonton Symptom Assessment System, NR = not reported.
↵* Measured by the modified ESAS, which ranges from 0 (symptom is absent) to 10 (worst possible symptom severity).
↵† Measured by the modified ESAS, which ranges from 0 (excellent quality of life) to 10 (very bad quality of life).
↵‡ Measured by the Multidimensional Fatigue Inventory, whereby each fatigue dimension receives a score out of 20 with a higher score indicating greater fatigue.
↵§ Effect size ≥ 0.35; p ≤ 0.01.
↵¶ Stable weight or increased weight at 2 mo.